α-Glucosidase Inhibitors from the Bark Extract of Ethno-Antidiabetic Ceriops tagal (Perr.) C.B. Rob

The bark of Ceriops tagal has been used in the Philippines for folk treatment diabetes mellitus (DM). Through an α-glucosidase inhibition assay guided isolation, constituents from detannified methanolic extract were isolated and identified to be methyl 2,4-dihydroxy-3,6- dimethyl benzoate (1), isopimar-7-ene-15S,16-diol (2), betulinic acid (3), lupeol (4), 2,4-dihydroxy-6-methyl (5). Compounds 3 (IC50 = 5.31 μM) 4 55.84 showed a more potent activity against than positive control, 1-deoxynojirimycin(IC50 79.16 μM). This is first report on presence weakly active compounds (1,2, 5) > 75 genus biological ofCompound 2. Enzyme kinetic studies suggested that uncompetitive type ofinhibitor, with as non-competitive type. study provides evidence possiblemechanism antidiabetic property C. associated its traditional use. It supportsthe possible utilization development prevent or treat diabetes.